Familial pancreatic cancer: what's new.
نویسنده
چکیده
منابع مشابه
Cancer Prone Disease Section
Alias: Familial pancreatic cancer Inheritance It has been estimated that as many as 10% of pancreatic cancers have a hereditary basis; five genetic syndromes have been identified that are associated with the familial aggregation of pancreatic cancer; these include: The second breast cancer syndrome (BRCA2), the familial atypical multiple mole melanoma (FAMMM), the Peutz-Jeghers Syndrome, the he...
متن کاملGene linked to pancreatic cancer.
A new study found that the ataxia tel-angiectasia mutated (ATM) gene — a gene linked with breast cancer and suspected in many others — may increase the hereditary risk for pancreatic cancer. According to the study, published in the January 2012 Cancer Discovery , knowledge of the presence of the ATM gene could lead to better screening for pancreatic cancer, the fourth-most-common cause of cance...
متن کاملPalladin Mutation Causes Familial Pancreatic Cancer and Suggests a New Cancer Mechanism
BACKGROUND Pancreatic cancer is a deadly disease. Discovery of the mutated genes that cause the inherited form(s) of the disease may shed light on the mechanism(s) of oncogenesis. Previously we isolated a susceptibility locus for familial pancreatic cancer to chromosome location 4q32-34. In this study, our goal was to discover the identity of the familial pancreatic cancer gene on 4q32 and dete...
متن کاملIncreased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients.
PURPOSE: Histologic findings in 51 pancreata resected from patients with a strong family history of pancreatic cancer were compared with the findings in 40 pancreata resected from patients with sporadic pancreatic cancer. None of the patients in the familial group had a known inherited syndrome other than familial pancreatic cancer. EXPERIMENTAL DESIGN: Precursor lesions, including pancreatic i...
متن کاملAbsence of deleterious palladin mutations in patients with familial pancreatic cancer.
It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer.
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عنوان ژورنال:
- JOP : Journal of the pancreas
دوره 8 6 شماره
صفحات -
تاریخ انتشار 2007